Qwo® is the first and only FDA-approved injectable for the treatment of moderate to severe cellulite in the buttocks of adult women. For most women, over time their skin thins, fat cells enlarge and push against the skin, and the fibrous bands under the skin’s surface thicken and cause tension. These factors working together cause cellulite’s signature dimples on the thighs and buttocks.
QWO is made from enzymes called collagenases. These enzymes are thought to target the structural causes under the skin, where cellulite starts. It’s thought that QWO works by releasing fibrous bands, redistributing fat cells, and stimulating the growth of new collagen. How QWO works in moderate to severe cellulite is not fully understood.
Endo Aesthetics conducted the largest clinical trials in the history of cellulite investigation to help determine the safety and efficacy of QWO. These two identical trials enrolled 845 women in the United States, aged 18 or older, with moderate to severe cellulite in the buttocks. Reductions in cellulite severity were observed more frequently in the QWO group compared to the placebo group as measured by the investigator and patient cellulite severity scales.
QWO may cause serious allergic reactions, including anaphylaxis, and injection site bruising.
Please see Important Safety Information below for more details.
Cellulite is a localized alteration (commonly referred to as a “dimple) in the contour of the skin that has been reported in approximately 90% of adult women of all races and ethnicities.
Over time, three completely normal things can happen. Fat cells get larger, skin gets thinner and a little looser and the fibrous bands under the skin’s surface get thicker, leading to a dimpled appearance.
Women are more likely to have cellulite than men, and it affects women of all shapes, sizes, ages and races.
Men have thicker skin than women do, and their collagen bands are oriented in a crisscross fashion, essentially eliminating the ability of the fat lobules to bulge through. If a man is given estrogen hormones (as in some cancer treatments), they can develop cellulite if there is enough fat.
Skin laxity happens as you age and can impact the appearance of cellulite.
Fat is not cellulite and does not cause it, but fat cells getting bigger between fibrous bands under the skin can contribute to a bumpy appearance.
Weight loss might reduce the appearance of cellulite but won’t get rid of it since it doesn’t address the fibrous bands under the skin’s surface.6 In some cases, weight loss can actually make cellulite look worse because of resulting skin laxity.
In an online Harris Poll survey of 2,006 women with cellulite, respondents said their cellulite was most commonly present in certain areas: 81% thighs, 66% butt, 42% stomach, 33% hips, 24% arms, 11% calves.8 Although cellulite can develop in various areas of the body, it mainly affects women and the predominant localization is on thighs and buttocks. This is because women tend to have more fatty deposits in these areas.
Topical treatments such as lotions, creams and scrubs have been used to temporarily reduce the appearance of cellulite.
Cellulite isn’t just a superficial problem—it’s actually quite deep. According to a recent Harris Poll online survey of 2,006 women, nearly half said they are bothered “a great deal” or “a lot” by their cellulite.
QWO is the first and only FDA-approved injectable for the treatment of moderate to severe cellulite in the buttocks of adult women.
Enzymes called collagenases target the structural causes under the skin, where cellulite starts. It’s thought that QWO works by releasing fibrous bands, redistributing fat cells, and stimulating the growth of new collagen. How QWO works in moderate to severe cellulite is not fully understood.
No. QWO is an injectable treatment option that is thought to target a primary structural cause of cellulite—the fibrous septae.1,2 The exact mechanism for the treatment of moderate to severe cellulite is unknown.
Your medical provider will determine if you are an appropriate candidate for QWO.
QWO is only approved for treatment of moderate to severe cellulite in the buttocks of adult women. Endo Aesthetics is continuing to investigate additional areas of treatment.
Each treatment visit may include up to two treatment areas. QWO injections will be given three weeks apart for a total of three treatment visits.
There are risks associated with this product. QWO may cause serious side effects including: allergic (hypersensitivity) reactions, including anaphylaxis, and injection site bruising. These are not all the side effects of QWO.
Do not receive QWO if you: are allergic to collagenase or to any of the ingredients in QWO, or have an active infection at the treatment area.
QWO may cause serious side effects, including:
Before receiving QWO, tell your healthcare provider if you:
Tell us about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Especially tell us if you take a medicine that prevents the clotting of your blood (antiplatelet or anticoagulant).
The most common side effects of QWO include: injection site bruising, pain, areas of hardness, itching, redness, discoloration, swelling and warmth in the treatment area.
These are not all the possible side effects of QWO. Call your healthcare provider for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
At Neaman Medi Spa, we pride ourselves in offering only the safest and effective treatment modalities. QWO Treatment is comfortable and has been proven to be safe and effective. Developing a treatment plan that will adequately achieve the results you are looking for is our priority. If you would like to improve your skin, reduce the appearance of fat and/or reduce the circumference of a particular body area, please contact Neaman Medi Spa at 844-338-5445 and schedule your consultation with one of our highly-trained nurse injectors. We welcome patients from the greater Portland, Salem, and Eugene areas.